DUTCH Cycle Mapping Plus

Women who are suffering from complicated issues with hormones, such as chronic headaches, fertility problems, PCOS, or stress that makes everything harder, would require more than just understanding their hormones for one day. The DUTCH Cycle Mapping Plus test was created specifically for this purpose. This test is a combination of hormone testing throughout the entire cycle and a full metabolite testing along with the Cortisol Awakening Response test.

Dutch cycle mapping

What Is the DUTCH Cycle Mapping Plus?

DUTCH Cycle Mapping Plus is an advanced hormone assessment for women by Precision Analytical Inc. This test unites the high resolution of estrogen and progesterone levels during the entire menstrual cycle (provided by the DUTCH Cycle Mapping) with the whole spectrum of hormone metabolites measured by the DUTCH Plus, along with the Cortisol Awakening Response (CAR).

Cortisol Awakening Response reflects the immediate surge in cortisol levels in the morning as a response to waking up. This is the way our body prepares itself to face the challenges of the upcoming day and provides an estimate of the resilience of the stress response system. Combining this with the whole cycle assessment provides clinicians with a unique combination: hormonal variations, their metabolism, and adrenal response to stress in one test.

This test is not intended for women on hormonal birth control.

What's Included in the Kit?

The DUTCH Cycle Mapping Plus kit provides for home sample collection and features urine and saliva collection devices:

  • Easiest sample collection protocol
  • 25 urine filter paper collection strips – for a complete cycle estimation of estradiol and progesterone
  • 6 Salivette saliva collection tubes – for Cortisol Awakening Response analysis
  • Patient information form, covering patient data, supplementation, medication use, hormone replacement, and health questionnaire
  • Return package

The presence of both urine strips and saliva tubes in the kit is due to the test itself requiring the collection of both types of samples because it estimates hormone fluctuations throughout the cycle by using urine and the morning cortisol peak by using saliva, the most precise method for CAR measurement.

What Do the Results Include?

The DUTCH Cycle Mapping Plus is among the most thorough hormone reports offered:

  • Nine (9) precise tests of estrogen and progesterone at strategic points throughout the entire menstrual cycle, examining the follicular, ovulatory, and luteal phases comprehensively
  • Test for 35 distinct hormones and hormone metabolites, including estrogen, progesterone, testosterone, DHEA-S, and cortisol; plus the full Cortisol Awakening Response (CAR) test
  • Charting of the hormone patterns throughout the cycle, allowing both practitioners and patients to easily see what’s going on for the month
  • Video tutorials embedded into the report to aid in explaining results to the practitioner
  • DUTCH OATs (Organic Acid Tests): oxidative stress marker 8-OHdG, melatonin (6-OHMS), and 6 organic acid tests, including B12 (methylmalonate), B6 (xanthurenate), kynurenate, glutathione (pyroglutamate), dopamine (homovanillate), and norepinephrine/epinephrine (vanilmandelate) 

When Is the DUTCH Cycle Mapping Plus Recommended?

While the regular DUTCH Cycle Mapping test looks at irregular cycles, fertility, and hormonal changes by phases of the cycle, the Cycle Mapping Plus digs deeper and looks at sexual and adrenal hormones, metabolism, and adrenal function. This test is ideal for:

  • Estrogen dominance – when elevated levels of estrogen compared to progesterone are seen throughout the cycle
  • Androgen dominance (or PCOS) – when the levels of testosterone and other androgens need to be seen in addition to the rest of the cycle
  • Preconception health – when a woman wants to have the most complete hormone profile before conception
  • Cortisol Awakening Response (CAR) testing – when the response to stress and the adrenal system function are of primary concern, along with the reproductive hormones

If your symptom profile includes migraines, fertility issues, PCOS, morning fatigue, stress, in addition to the hormonal imbalances associated with your menstrual cycle, then the DUTCH Cycle Mapping Plus is made just for you.

Why DUTCH Cycle Mapping Plus Over Other Options?

Captures what single-day tests miss

Salivary hormone testing might fail to detect key progesterone and estrogen peaks without proper timing, a serious issue for women who have irregular cycles. With the DUTCH Cycle Mapping Plus test, several first morning urine tests are conducted and calibrated in accordance with the length of the cycle, allowing for the capture of ovulatory and luteal peaks of any cycle length.

Better testing drives better treatment

Having a complete graphical representation of the menstrual cycle enables providers to monitor ovulation and discover the source of spotting or migraines during mid-cycle and determine ovarian health. Along with the information about metabolites and CAR, this will allow creating an individually tailored therapy plan for each patient.

Analytically rigorous methodology

Estrogen and progesterone metabolites are analyzed nine times with the help of liquid chromatography tandem mass spectrometry – the most precise method of detecting these hormones in urine.

How Does It Compare to Other DUTCH Tests?

Feature

DUTCH Complete

DUTCH Plus

DUTCH Cycle Mapping

DUTCH Cycle Mapping Plus

Comprehensive sex hormones and metabolites

Yes

Yes

No

Yes

Diurnal cortisol rhythm

Yes

Yes

No

No

Cortisol metabolism

Yes

Yes

No

Yes

Cortisol Awakening Response (CAR)

No

Yes

No

Yes

Organic acids and overnight melatonin

Yes

Yes

No

Yes

Menstrual cycle estrogen and progesterone mapping

No

No

Yes

Yes

DUTCH Cycle Mapping Plus is the only test that offers a combination of full-cycle hormone mapping, metabolism profiling, CYP450 analysis, and organic acids. It’s the most comprehensive test that applies to women who experience symptoms that affect reproduction, adrenals, and metabolism altogether.

In case you have doubts concerning which test is best suited for you – the DUTCH Cycle Mapping or the Cycle Mapping Plus – feel free to book a free consult at dutchtesting.org

Frequently Asked Questions

What is the DUTCH Cycle Mapping Plus?

It is an exclusively female hormone test that includes full-cycle monitoring of estrogen and progesterone levels, along with a detailed evaluation of 35 hormone metabolites and Cortisol Awakening Response (CAR). It is the most advanced testing option offered by the DUTCH test kit for women with complex hormonal problems.

How is the DUTCH Cycle Mapping Plus different from the DUTCH Cycle Mapping?

While the basic Cycle Mapping provides the estrogen and progesterone monitoring across the entire menstrual cycle without any additional tests, the Cycle Mapping Plus incorporates the measurement of hormone metabolites, organic acids, and Cortisol Awakening Response (CAR).

How many samples are required for the DUTCH Cycle Mapping Plus?

This test requires 25 dried urine filter papers for full-cycle estrogen and progesterone tracking, along with six Salivette tubes for CAR measuring in the first hour after waking up.

Who is the DUTCH Cycle Mapping Plus best suited for?

This product works well for women who suffer from either estrogen dominance or androgen dominance, or PCOS, fertility issues, migraines due to hormones, and chronic stress, which can affect one’s menstrual cycles.

Can I take this test if I'm on birth control?

No. The DUTCH Cycle Mapping Plus test does not suit women who use hormonal birth control. This is because birth control alters your natural hormonal balance.

What does the Cortisol Awakening Response (CAR) measure?

The CAR is an indicator of the rapid increase of cortisol during the first 30-60 minutes after awakening, which is associated with proper functioning of the HPA axis, i.e., the communication network between the brain and adrenal glands. This index can help us understand our stress resistance, susceptibility to burnout, and fatigue in the morning.

Do I need a healthcare provider to order the DUTCH Cycle Mapping Plus?

Yes, as in any other DUTCH test, you will need to go through the process of ordering DUTCH Cycle Mapping Plus through a healthcare or functional medicine professional.