DUTCH Complete Test

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Sex Hormones

• Estrogens – E2, E1, and E3, as well as their metabolites such as the 2-OH, 4-OH, and 16-OH estrogen metabolites
• Progesterone and its metabolites
• Testosterone and its metabolites, including androsterone and etiocholanolone
• DHEA-S – a major adrenal precursor hormone 

Adrenal and Cortisol Markers

• Daily rhythm of free cortisol levels – measured through multiple time points, thus enabling measurement of the diurnal rhythm of cortisol, which provides information on adrenal insufficiency and chronic stress.
• Metabolized cortisol level – measures total cortisol production, not just the current level of cortisol.
• Cortisone – inactive form of cortisol, necessary for measuring cortisol/cortisone conversion. 

DUTCH OATs (Organic Acid Tests)

One of the most distinctive features of DUTCH Complete is that it tests your organic acids; it is something that standard hormone blood test does not do:

• 8-OHdG – it is an oxidative stress marker showing free radical-induced DNA damage
• Melatonin (6-OHMS) – it is evaluated as an overnight urinary metabolite and helps understand sleep hormone production
• Methylmalonic acid – it shows the state of Vitamin B12
• Xanthurenic acid – it shows the state of Vitamin B6
• Kynurenic acid – it reflects tryptophan catabolism and immunity-inflammatory response
• Pyroglutamic acid – it shows the state of glutathione and antioxidant capacity
• Homovanillic acid – it shows dopamine catabolism
• Vanilmandelic acid – it shows norepinephrine and epinephrine catabolism.

All these organic acids show a metabolic profile going far beyond the hormonal one.

The kit is intended for simple at-home testing. What you can expect to get inside:

• Clear collection instructions
• Four dried urine collection strips
• Requisition form, which includes personal information, supplement information, medications, hormone replacement therapy, and a health survey
• Prepaid, sealed envelope for return

Collection entails four or five dried urine samples collected at certain times during 24 hours – usually in the late afternoon, just before bedtime, early morning, and two hours after.

Dried urine samples have a shelf life of several weeks; therefore, it makes shipping both domestically and internationally easy without refrigeration.

The DUTCH Complete test report is an in-depth report that includes everything necessary for easy interpretation, both for the providers and for the patients themselves. These include:

• A detailed analysis of all 35 hormones and their metabolites, with reference ranges included in charts
• Daily free cortisol profiles, to illustrate the cortisol curve
• Graphical analysis of hormone levels, with appropriate context
• Video guides are included in the report to assist providers in explaining the results
• Organic acid results, with clinical context for every marker

Reports for both men and women samples can be found on the official Precision Analytical website, showing the level of detail that can be seen in the report output.

The DUTCH Complete is especially ideal when you are searching for information on:

• Sex hormone synthesis and metabolism – sex hormone levels, such as estrogen, progesterone, and testosterone, along with the way in which the body metabolizes them
• Hormones secreted by the adrenal glands – DHEA, free cortisol, and its metabolism
• Daily cortisol and cortisone rhythms – the way that cortisol fluctuates throughout the day
• Melatonin synthesis during the night – important for understanding sleep cycle disruptions
• Availability of micronutrients and oxidative stress – using the specialized Organic Acid panel

In practice, the DUTCH Complete test is frequently used in patients suffering from fatigue, weight gain or loss, mood changes, brain fog, low libido, irregular menstruation, hair loss, poor sleep quality, PCOS, perimenopause, menopause, or chronic stress.

Several things set the DUTCH Complete apart from conventional hormone testing:

Easier, more natural collection

Instead of drawing blood from the patient at a clinic or collecting a 24-hour liquid urine sample, patients take four or five dried urine samples over the course of one day at home.

Comprehensive reporting

The DUTCH Complete provides the most comprehensive panel of sex and adrenal hormones and metabolites that can be obtained in a single test. Patients get information in this test that will enable providers to take action based on results and create an effective treatment plan.

Backed by research

A lot of research has been conducted by Precision Analytical in order to validate the scientific method of their hormone test. This is done using mass spectrometry – a very sensitive analysis process.

Effective HRT monitoring

This makes the DUTCH Complete ideal for testing most forms of bioidentical hormone replacement therapy, because through its ability to measure how the hormones being used are being absorbed and metabolized, it provides information needed to ensure proper dosing of the hormones, rather than using any guesswork.

Expert education and clinical support

Registered providers of the DUTCH test have access to comprehensive educational materials to interpret results. There is also clinical support from Precision Analytical’s team of clinical educators who provide training either individually or in groups in interpreting patient reports.

Choosing the right version of the DUTCH test matters. Here’s how the DUTCH Complete compares to the other main options:

The DUTCH Plus test includes the Cortisol Awakening Response (CAR), which is a series of cortisol measurements taken during the first hour after waking, which gives us further information about the function of the hypothalamus-pituitary-adrenal axis and morning cortisol production. This is a good choice for people suffering from serious burnout, morning fatigue, or problems with the HPA axis.

The DUTCH Cycle Mapping evaluates the levels of estrogen and progesterone throughout the whole menstrual cycle, not just on one day. This test is recommended for women who have problems with infertility, irregular menstruation, or cycle-related hormones.

In most cases, the DUTCH Complete test should be the first step to hormone and adrenal health testing.

The DUTCH Complete test is an excellent choice for people who:

• Have consistent hormonal issues that cannot be accounted for through regular blood work
• Are you going through perimenopause, menopause, and/or andropause
• Are you dealing with PCOS, endometriosis, PMS, and/or fertility problems
• Feel like they may have adrenal imbalances or are stressed out
• Are taking hormones and want to know how their body is processing them
• Are you looking for a full hormonal panel to assess for the prevention or optimization health program

If you’re not sure about which DUTCH test is most appropriate for you, then consulting a functional medicine doctor or getting a free consultation from dutchtesting.org is your best bet.

The DUTCH Complete Test has certainly lived up to its name as one of the most comprehensive tests on the market when it comes to hormonal health. The fact that it can analyze not only the levels of hormones in the body but also the metabolic pathway in which those hormones travel makes the findings much more applicable and actionable.

While it cannot replace a proper diagnosis from a medical professional, the DUTCH Complete Test does stand out as one of the best ways to truly understand what’s going on in your hormonal metabolism.